Read e-book online Parkinson's Disease - A Medical Dictionary, Bibliography, PDF

By Icon Health Publications

ISBN-10: 0597841535

ISBN-13: 9780597841538

ISBN-10: 1417510781

ISBN-13: 9781417510788

This can be a 3-in-1 reference booklet. It supplies a whole scientific dictionary protecting thousands of phrases and expressions with regards to Parkinson's sickness. It additionally provides large lists of bibliographic citations. eventually, it offers details to clients on the way to replace their wisdom utilizing numerous web assets. The booklet is designed for physicians, scientific scholars getting ready for Board examinations, scientific researchers, and sufferers who are looking to get to grips with study devoted to Parkinson's disorder. in the event that your time is efficacious, this publication is for you. First, you won't waste time looking out the net whereas lacking loads of appropriate info. moment, the booklet additionally saves you time indexing and defining entries. ultimately, you won't waste money and time printing 1000s of web content.

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Additional info for Parkinson's Disease - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

Sample text

Professor; Neurology; Boston University Medical Campus 715 Albany St, 560 Boston, Ma 02118 Timing: Fiscal Year 2002; Project Start 30-SEP-1997; Project End 31-JUL-2007 Summary: (provided by applicant): The cause of idiopathic Parkinson's disease (PD), a debilitating disease that afflicts an estimated 1 percent of persons age 60 or older, remains unknown. In this application, we propose genetic epidemiological studies, genetic linkage studies, and candidate gene studies for PD. In the past four years, we have established a ulti-institutional research program that has collected 300 PD affected sibling pairs and extended families.

However, their use has been limited by high doses of vectors needed, vector-cytotoxicity, short-term transgene expression, and deleterious effects of anti-adenovirus inflammatory and immune responses. These limitations are due to: (i) low efficiency of transcriptional promoter elements currently used, which directly leads to the need to use higher doses of vectors, and (ii) cytotoxicity and immunogenicity of viral proteins expressed from the genomes of first generation adenoviral vectors. We now wish to initiate the next stage in the design of efficient, safe, long-term expressing vectors for neurological gene therapy.

Studies with "F-fluoro-deoxyglucose (FDG) and PET have demonstrated an abnormal metabolic network in clinically non-manifesting carriers of Idiopathic Torsion Dystonia (ITD) DYT I gene. In preliminary studies, we have found that motor sequence learning may be impaired in these same gene carriers. We plan to complete the psychophysical studies in non-manifesting DYTI carriers and to assess the effect of GPiDBS on rcbf in affected DYTI patients. Specifically, we will ask the following questions: Will non-manifesting DYTI carriers show motor learning and network activation abnormalities that parallel their resting metabolic abnormalities?

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Parkinson's Disease - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by Icon Health Publications


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