By A. Bulikova
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Extra info for Antiphospholipid Syndrome
Proc Natl Acad Sci U S A. 95(26), 15542-15546. Jankowski M, Vreys I, Wittevrongel C, Boon D, Vermylen J, Hoylaerts MF & Arnout J. (2003) Thrombogenicity of beta 2-glycoprotein I-dependent antiphospholipid antibodies in a photochemically induced thrombosis model in the hamster. Blood. 101(1), 157162. Koike T, Ichikawa K, Kasahara H, Atsumi T, Tsutsumi A & Matsuura E. (1998) Epitopes on beta2-GPI recognized by anticardiolipin antibodies. Lupus. 7 Suppl 2, S14-7. Lee NS, Brewer HB Jr & Osborne JC Jr.
8(1), 32-43. 34 Antiphospholipid Syndrome Willems GM, Janssen MP, Pelsers MM, Comfurius P, Galli M, Zwaal RF & Bevers EM. (1996) Role of divalency in the high-affinity binding of anticardiolipin antibodybeta 2-glycoprotein I complexes to lipid membranes. Biochemistry. 35(43), 1383313842. 3 Genetics of Antiphospholipid Syndrome Jesús Castro-Marrero, Eva Balada, Josep Ordi-Ros and Miquel Vilardell-Tarrés Systemic Autoimmune Diseases Research Unit, Vall d’Hebron University Hospital Research Institute Universitat Autónoma de Barcelona, Barcelona Spain 1.
Results of those studies in which HLA polymorphisms have been investigated by molecular methods overlap those obtained by serological typing. It is difficult to discriminate whether DR loci contribute to this genetic susceptibility more than DQ loci, because they are in strong linkage disequilibrium. 4. Prothrombotic risk factors in antiphospholipid syndrome Antiphospholipid antibodies (aPL) are related to thrombosis in APS and thromboses are, together with obstetric complications, the main clinical manifestations of APS.
Antiphospholipid Syndrome by A. Bulikova